Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility

PA Dugué; CH Jung; JE Joo; X Wang; EM Wong; E Makalic; DF Schmidt; L Baglietto; G Severi; MC Southey; DR English; GG Giles; RL Milne

Journal article

Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility

PA Dugué, CH Jung, JE Joo, X Wang, EM Wong, E Makalic, DF Schmidt, L Baglietto, G Severi, MC Southey, DR English, GG Giles, RL Milne

Epigenetics | TAYLOR & FRANCIS INC | Published : 2020

DOI: 10.1080/15592294.2019.1668739

Abstract

We conducted a genome-wide association study of blood DNA methylation and smoking, attempted replication of previously discovered associations, and assessed the reversibility of smoking-associated methylation changes. DNA methylation was measured in baseline peripheral blood samples for 5,044 participants in the Melbourne Collaborative Cohort Study. For 1,032 participants, these measures were repeated using blood samples collected at follow-up, a median of 11 years later. A cross-sectional analysis of the association between smoking and DNA methylation and a longitudinal analysis of changes in smoking status and changes in DNA methylation were conducted. We used our cross-sectional analysis ..

View full abstract

University of Melbourne Researchers

Pierre-Antoine Dugue Author

Chol-Hee Jung Author

Eric Joo Author

Enes Makalic Author

Related Projects (6)

A PROSPECTIVE STUDY OF THE INFLUENCE OF HEALTH - RELATED LIFESTYLE FACTORS ON DNA METHYLATION

It is known that DNA methylation can lead to disease. We aim to discover what causes DNA methylation to change. This could open the way for ..

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based..

Methylation of DNA and colorectal cancer

Methylation of DNA involves a change to the chemical composition of DNA. It can affect the function of genes and normal methylation is essen..

METHYLATION AND THE RISK OF UROTHELIAL CELL CANCER

Why don’t we run prevention programs for urinary tract cancers like we do for others? It’s because we don’t know which lifestyle factors, ex..

Epidemiology of chronic disease, health interventions and DNA studies

METHYLATION AS A RISK FACTOR FOR PROSTATE CANCER

DNA methylation is a process that plays a critical role throughout life by altering the expression of genes. We aim to investigate the poten..

Grants

Awarded by VicHealth

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) [grant 1088405]. MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. Cases were ascertained through the Victorian Cancer Registry (VCR) and the Australian Cancer Database (Australian Institute of Health and Welfare). The nested case-control methylation studies were supported by the NHMRC grants 1011618, 1026892, 1027505, 1050198, 1043616 and 1074383. M.C.S. is an NHMRC Senior Research Fellow (1155163).